Shareholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands		6 Months Ended
	Jun. 16, 2022	Jun. 30, 2022	Jun. 30, 2021
Equity [Line Items]
Proceeds from issuance of ordinary shares, net		$ 51,464
Warrant or Right, Original issuance date, description		On June 16, 2022, the Company closed an underwritten offering (the “June 2022 Offering”) in which the Company issued and sold 25,464,483 of the Company’s ordinary shares at a price of $2.15 per share and pre-funded warrants (the “Pre-Funded Warrants”) to purchase up to 7,093,656 of the Company’s ordinary shares at an offering price of $2.1499 per Pre-Funded Warrant, which represents the per share offering price for the ordinary shares less the $0.0001 per share exercise price for each Pre-Funded Warrant. These Pre-Funded Warrants were recorded as a component of shareholders’ equity within additional paid-in capital. The gross proceeds to the Company were $70.0 million before deducting underwriting discounts and commissions and other offering expenses. The net proceeds of the June 2022 Offering were approximately $65.5 million. The Pre-Funded Warrants are exercisable at any time after their original issuance and on or prior to the five-year anniversary of the original issuance date. A holder of Pre-Funded Warrants may not exercise the warrant if the holder, together with its affiliates, would beneficially own more than 19.99% of the number of ordinary shares outstanding or more than 19.99% of the combined voting power of the Company’s securities outstanding immediately after giving effect to such exercise, unless and until shareholder approval is obtained.
At-The-Market Equity Program [Member]
Equity [Line Items]
Proceeds from issuance of ordinary shares, net		$ 1,105	$ 13,150
June 2022 Offering [Member]
Equity [Line Items]
Issuance of ordinary shares, shares	25,464,483
Purchase price per share	$ 2.15
Gross proceeds from sale of ordinary shares	$ 70,000
Proceeds from issuance of ordinary shares, net	$ 65,500
Pre Funded Warrants (Member)
Equity [Line Items]
Purchase price per share	$ 2.1499
Pre-funded warrant exercise price per share	$ 0.0001
Minimum percentage of combined voting power of securities outstanding immediate effect of exercise	19.99%
Pre Funded Warrants (Member) | Minimum [Member]
Equity [Line Items]
Percentage of ownership interest in ordinary shares outstanding	19.99%
Pre Funded Warrants (Member) | Maximum [Member]
Equity [Line Items]
Purchase price of pre-funded warrants	7,093,656