X0306 4 2022-10-27 0 0001631574 Wave Life Sciences Ltd. WVE 0001572315 Verdine Gregory L. C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 1 0 0 0 Share Option (right to buy) 4.37 2022-10-27 4 A 0 163467 0.00 A 2027-10-27 Ordinary Shares 163467 163467 D The reporting person was granted this option pursuant to his existing consulting agreement with Wave. The option vests in equal monthly installments beginning on October 31, 2022, through December 31, 2024, subject to the reporting person's continued services through the applicable vesting date. /s/ Gregory L. Verdine 2022-10-28