X0206 3 2020-01-09 0 0001631574 Wave Life Sciences Ltd. WVE 0001799784 Gaiero David G C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 0 1 0 0 Interim CFO Ordinary Shares 7043 D Share Option (Right to Buy) 22.10 2027-10-03 Ordinary Shares 19000 D Consists of 541 ordinary shares; 2,502 restricted share units (RSUs) that vest in four equal annual installments beginning on February 1, 2019 through February 1, 2022; and 4,000 RSUs that vest in four equal annual installments of 25% beginning on February 1, 2020 through February 1, 2023. The option vests as to 25% of the shares on July 10, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until July 10, 2021. Exhibit 24.1 - Power of Attorney /s/ David Gaiero 2020-01-17