X0306 4 2019-11-20 0 0001631574 Wave Life Sciences Ltd. WVE 0001572315 Verdine Gregory L. C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE CAMBRIDGE MA 02138 1 0 0 0 Ordinary Shares 2019-11-20 4 S 0 24030 30.27 D 36009 D Ordinary Shares 2019-11-20 4 S 0 3400 31.59 D 32609 D Ordinary Shares 2019-11-20 4 S 0 2609 32.74 D 30000 D The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $30.07 to $31.045 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $31.50 to $32.04 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $32.69 to $32.76 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. /s/ Gregory L. Verdine 2019-11-22