X0306 4 2019-02-19 0 0001631574 Wave Life Sciences Ltd. WVE 0001657675 Vargeese Chandra C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 0 1 0 0 Senior VP, Drug Discovery Ordinary Shares 2019-02-19 4 S 0 2055 36.84 D 25245 D On February 19, 2019, the reporting person sold 2,055 ordinary shares solely to cover taxes associated with the vesting of restricted share units on February 15, 2019. These sales were made pursuant to a 10b5-1 Trading Plan. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $36.83 to $37.4865 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. /s/ Chandra Vargeese 2019-02-21