X0306 4 2019-02-19 0 0001631574 Wave Life Sciences Ltd. WVE 0001657709 Francis Chris C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 0 1 0 0 See Remarks Ordinary Shares 2019-02-19 4 S 0 1709 36.8397 D 20368 D On February 19, 2019, the reporting person sold 1,709 ordinary shares solely to cover taxes associated with the vesting of restricted share units on February 15, 2019. These sales were made pursuant to a 10b5-1 Trading Plan. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $36.83 to $37.4713 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.1 SVP, Corporate Development, Head of Emerging Areas /s/ Chris Francis 2019-02-21