X0306 4 2017-03-29 0 0001631574 Wave Life Sciences Ltd. WVE 0001657771 Tanaka Masaharu C/O KAGOSHIMA SHINSANGYO SOUSEI INVEST. L.P., 1-3-34 MEIZAN-CHO, KAGOSHIMA CITY KAGOSHIMA M0 891-0122 JAPAN 1 0 1 0 0001657769 Kagoshima Shinsangyo Sousei Investment Limited Partnership 1-3-34 MEIZAN-CHO, KAGOSHIMA CITY KAGOSHIMA M0 891-0122 JAPAN 0 0 1 0 Ordinary Shares 2017-03-29 4 S 0 433825 24.91 D 2794865 I See Footnote The aggregate purchase price for the 433,825 Ordinary Shares was 1,199,998,712 Japanese yen. The purchase price per share in Column 4 of Table I was calculated based on the aggregate purchase price divided by the number of Ordinary Shares sold. The purchase price per share is shown in U.S. dollars and was converted based on the currency exchange rate as of the transaction date, March 29, 2017, rounded to the nearest whole cent. Shares held by Kagoshima Shinsangyo Sousei Investment Limited Partnership ("KSS"). Masaharu Tanaka, a director of the Issuer, is the representative director of Kagoshima Development Co., Ltd., the general partner of KSS and may be deemed to beneficially own the reported securities. Pursuant to Rule 16a-1 under the Securities Exchange Act of 1934, as amended (the "Act"), Mr. Tanaka disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. The filing of this Form 4 shall not be construed as an admission that Mr. Tanaka is or was for the purposes of Section 16(a) of the Act, or otherwise, the beneficial owner of any of the reported securities. /s/ Masaharu Tanaka 2017-03-31 Kagoshima Shinsangyo Sousei Investment Limited Partnership, By: Kagoshima Development Co. Ltd., Its: General Partner, By: /s/ Masaharu Tanaka, Masaharu Tanaka, its representative director 2017-03-31