X0306 4 2015-08-14 0 0001631574 Wave Life Sciences Ltd. WVE 0001657771 Tanaka Masaharu C/O KAGOSHIMA SHINSANGYO SOUSEI INVEST. LTD. P., 6-1-20, NANEI, KAGOSHIMA CITY KAGOSHIMA M0 891-0122 JAPAN 1 0 1 0 0001657769 Kagoshima Shinsangyo Sousei Investment Limited Partnership 6-1-20, NANEI, KAGOSHIMA CITY KAGOSHIMA M0 891-0122 JAPAN 0 0 1 0 Ordinary Shares 2015-11-16 4 C 0 161663 A 3152440 I See Footnote Ordinary Shares 2015-11-16 4 P 0 76250 16.00 A 3228690 I See Footnote Series B Preferred Shares 2015-08-14 4 P 0 161663 12.37 A Ordinary Shares 161663 161663 I See Footnote Series B Preferred Shares 2015-11-16 4 C 0 161663 D Ordinary Shares 161663 0 I See Footnote The Series B Preferred Shares converted into Ordinary Shares on a one-for-one basis upon the closing of the Issuer's initial public offering of its Ordinary Shares and had no expiration date. Shares held by Kagoshima Shinsangyo Sousei Investment Limited Partnership ("KSS"). Masaharu Tanaka, a director of the Issuer, is the representative director of Kagoshima Development Co., Ltd., the general partner of KSS and may be deemed to beneficially own the reported securities. Pursuant to Rule 16a-1 under the Securities Exchange Act of 1934, as amended (the "Act"), Mr. Tanaka disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. The filing of this Form 4 shall not be construed as an admission that Mr. Tanaka is or was for the purposes of Section 16(a) of the Act, or otherwise, the beneficial owner of any of the reported securities. Share amounts reflect a 4.0415917-for-1 forward split of the Issuer's shares on November 1, 2015. The securities were purchased for $12.37 per share on a post-split basis. /s/ Masaharu Tanaka 2015-11-17 Kagoshima Shinsangyo Sousei Investment Limited Partnership, By: Kagoshima Development Co. Ltd., Its: General Partner, By: /s/ Masaharu Tanaka, Masaharu Tanaka, its representative director 2015-11-17