Attorney-in-Fact

0001104659-20-094764.txt : 20200813 0001104659-20-094764.hdr.sgml : 20200813 20200813171234 ACCESSION NUMBER: 0001104659-20-094764 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20200630 FILED AS OF DATE: 20200813 DATE AS OF CHANGE: 20200813 EFFECTIVENESS DATE: 20200813 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Sofinnova Investments, Inc. CENTRAL INDEX KEY: 0001631134 IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-18774 FILM NUMBER: 201100216 BUSINESS ADDRESS: STREET 1: 3000 Sand Hill Road STREET 2: BUILDING 4-SUITE 250 CITY: Menlo Park STATE: CA ZIP: 94025 BUSINESS PHONE: 650.681.8428 MAIL ADDRESS: STREET 1: 3000 Sand Hill Road STREET 2: BUILDING 4-SUITE 250 CITY: Menlo Park STATE: CA ZIP: 94025 FORMER COMPANY: FORMER CONFORMED NAME: Sofinnova Ventures Inc DATE OF NAME CHANGE: 20150120 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001631134 XXXXXXXX 06-30-2020 06-30-2020 false Sofinnova Investments, Inc.

3000 Sand Hill Road Building 4-Suite 250 Menlo Park CA 94025

13F HOLDINGS REPORT 028-18774 Y Sofinnova Investments, Inc. is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, Sofinnova Management VII, L.L.C., Sofinnova Management VIII, L.L.C., Sofinnova Management IX, L.L.C., Sofinnova Management X, L.L.C., and Sofinnova BioEquities GP LLC. Nathalie Auber Attorney-in-Fact 650-681-8428 /s/ Nathalie Auber Menlo Park CA 08-13-2020 2 186 1586248 1 0001536054 028-14917 Crestline Management, LP 2 0001753711 Blackstone Alternative Asset Management L.P. INFORMATION TABLE 2 infotable.xml Aclaris Therapeutics COMM 00461U105 3097 1911573 SH SOLE 1911573 0 0 Akouos, Inc ADR 00973J101 34089 1515073 SH SOLE 1515073 0 0 Amarin ADR 023111206 36041 5208305 SH SOLE 5208305 0 0 Apellis Pharmaceuticals, Inc COMM 03753U106 1619 49580 SH SOLE 49580 0 0 Ascendis Pharma A/S ADR 04351P101 164150 1109874 SH SOLE 1109874 0 0 Chiasma COMM 16706W102 8771 1630221 SH SOLE 1630221 0 0 Coherus BioSciences COMM 19249H103 34527 1933221 SH SOLE 1933221 0 0 Entasis Therapeutics Holdings Inc. COMM 293614103 3493 1180178 SH SOLE 1180178 0 0 Galera Therapeutics, Inc COMM 36338D108 22018 3083712 SH SOLE 3083712 0 0 Karuna Therapeutics, Inc. COMM 48576A100 210169 1885602 SH SOLE 1885602 0 0 Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 20634 809803 SH SOLE 809803 0 0 Merus N.V. COMM N5749R100 21095 1311039 SH SOLE 1311039 0 0 Natera COMM 632307104 154594 3100560 SH SOLE 3100560 0 0 Nextcure, Inc COMM 65343E108 57285 2671856 SH SOLE 2671856 0 0 Nucana Biomed Ltd ADR 67022C106 12263 2266666 SH SOLE 2266666 0 0 Nucana Biomed Ltd Ordinary Shares GBOOBYWYV 12984 2400000 SH SOLE 2400000 0 0 ObsEva SA COMM H5861P103 27975 4749623 SH SOLE 4749623 0 0 PDS Biotechnology Corporation COMM 70465T107 287 142635 SH SOLE 142635 0 0 Principia Biopharma COMM 74257L108 84738 1417258 SH SOLE 1417258 0 0 Synlogic Inc. COMM 87166L100 1167 574972 SH SOLE 574972 0 0 Y-mAbs Therapeutics, Inc COMM 984241109 94793 2194278 SH SOLE 2194278 0 0 Abbvie Inc COMM 00287Y109 10772 109717 SH SOLE 109717 0 0 Acceleron Pharma Inc COMM 00434H108 9016 94641 SH SOLE 94641 0 0 Akebia Therapeutics Inc COMM 00972D105 4032 296912 SH SOLE 296912 0 0 Alnylam Pharmaceuticals Inc COMM 02043Q907 9672 65300 SH Call SOLE 65300 0 0 Amgen Inc COMM 031162950 17336 73500 SH Put SOLE 73500 0 0 Applied Genetic Technologies Corp COMM 03820J100 2582 466103 SH SOLE 466103 0 0 Arena Pharmaceuticals Inc COMM 040047607 382 6065 SH SOLE 6065 0 0 Axsome Therapeutics Inc COMM 05464T104 3116 37871 SH SOLE 37871 0 0 BioCryst Pharmaceuticals Inc COMM 09058V103 2821 592106 SH SOLE 592106 0 0 Biomarin Pharmaceutical Inc COMM 09061G101 3378 27390 SH SOLE 27390 0 0 Blueprint Medicines Corp COMM 09627Y109 3231 41427 SH SOLE 41427 0 0 Calithera Biosciences Inc COMM 13089P101 2092 396177 SH SOLE 396177 0 0 ChemoCentryx Inc COMM 16383L106 2428 42192 SH SOLE 42192 0 0 Compugen Ltd COMM M25722105 678 45107 SH SOLE 45107 0 0 Constellation Pharmaceuticals Inc COMM 210373106 2709 90144 SH SOLE 90144 0 0 Cytokinetics Inc COMM 23282W605 1644 69767 SH SOLE 69767 0 0 Eli Lilly & Co COMM 532457108 10644 64834 SH SOLE 64834 0 0 Gilead Sciences Inc COMM 375558103 13519 175706 SH SOLE 175706 0 0 SPDR Ser Tr S&P Biotech 81369Y959 6535 65300 SH Put SOLE 65300 0 0 Homology Medicines Inc COMM 438083107 2185 143831 SH SOLE 143831 0 0 Horizon Therapeutics PLC COMM G46188101 6120 110120 SH SOLE 110120 0 0 Immunovant Inc COMM 45258J102 447 18338 SH SOLE 18338 0 0 Insmed Inc COMM 457669307 5801 210646 SH SOLE 210646 0 0 Intellia Therapeutics Inc COMM 45826J105 527 25050 SH SOLE 25050 0 0 Intra-Cellular Therapies Inc COMM 46116X101 2704 105346 SH SOLE 105346 0 0 Intra-Cellular Therapies Inc COMM 46116X951 2462 95900 SH Put SOLE 95900 0 0 Invesco QQQ Trust UNIT SER 1 46090E953 3244 13100 SH Put SOLE 13100 0 0 Jazz Pharmaceuticals PLC COMM G50871105 11693 105975 SH SOLE 105975 0 0 Kadmon Holdings Inc COMM 48283N106 3412 666381 SH SOLE 666381 0 0 Kala Pharmaceuticals Inc COMM 483119103 2319 220610 SH SOLE 220610 0 0 Kura Oncology Inc COMM 50127T109 4337 266058 SH SOLE 266058 0 0 Liquidia Technologies Inc COMM 53635D202 2933 348305 SH SOLE 348305 0 0 Menlo Therapeutics Inc COMM 586858102 547 316027 SH SOLE 316027 0 0 Merck & Co Inc COMM 58933Y105 15233 196985 SH SOLE 196985 0 0 Mersana Therapeutics Inc COMM 59045L106 1408 60184 SH SOLE 60184 0 0 Mirati Therapeutics Inc COMM 60468T105 401 3514 SH SOLE 3514 0 0 Mirum Pharmaceuticals Inc COMM 604749101 4590 235882 SH SOLE 235882 0 0 MyoKardia Inc COMM 62857M105 4718 48826 SH SOLE 48826 0 0 Novocure Ltd COMM G6674U908 1293 21800 SH Call SOLE 21800 0 0 Oric Pharmaceuticals Inc COMM 68622P109 255 7569 SH SOLE 7569 0 0 Otonomy Inc COMM 68906L105 2672 738154 SH SOLE 738154 0 0 PTC Therapeutics Inc COMM 69366J200 9710 191358 SH SOLE 191358 0 0 PTC Therapeutics Inc COMM 69366J900 1324 26100 SH Call SOLE 26100 0 0 Pfizer Inc COMM 717081903 2492 76200 SH Call SOLE 76200 0 0 Protagonist Therapeutics Inc COMM 74366E102 2508 142020 SH SOLE 142020 0 0 Puma Biotechnology Inc COMM 74587V107 5427 520370 SH SOLE 520370 0 0 Reata Pharmaceuticals Inc COMM 75615P103 886 5680 SH SOLE 5680 0 0 Rigel Pharmaceuticals Inc COMM 766559603 271 147828 SH SOLE 147828 0 0 SPDR Ser Tr S&P Biotech 78464A950 7310 65300 SH Put SOLE 65300 0 0 Supernus Pharmaceuticals Inc COMM 868459108 4959 208815 SH SOLE 208815 0 0 Syndax Pharmaceuticals Inc COMM 87164F105 601 40583 SH SOLE 40583 0 0 TG Therapeutics Inc COMM 88322Q108 5910 303374 SH SOLE 303374 0 0 United Therapeutics Corp COMM 91307C102 16048 132624 SH SOLE 132624 0 0 Zymeworks Inc COMM 98985W102 4394 121815 SH SOLE 121815 0 0 iShares Tr Russell 2000 ETF 464287955 4367 30500 SH Put SOLE 30500 0 0 Abbvie Inc COMM 00287Y109 4067 41422 SH OTR 1 41422 0 0 Acceleron Pharma Inc COMM 00434H108 3408 35774 SH OTR 1 35774 0 0 Akebia Therapeutics Inc COMM 00972D105 1525 112262 SH OTR 1 112262 0 0 Alnylam Pharmaceuticals Inc COMM 02043Q907 3658 24700 SH Call OTR 1 24700 0 0 Amgen Inc COMM 031162950 6510 27600 SH Put OTR 1 27600 0 0 Applied Genetic Technologies Corp COMM 03820J100 973 175613 SH OTR 1 175613 0 0 Arena Pharmaceuticals Inc COMM 040047607 144 2292 SH OTR 1 2292 0 0 Axsome Therapeutics Inc COMM 05464T104 1178 14319 SH OTR 1 14319 0 0 BioCryst Pharmaceuticals Inc COMM 09058V103 1063 223133 SH OTR 1 223133 0 0 Biomarin Pharmaceutical Inc COMM 09061G101 1275 10340 SH OTR 1 10340 0 0 Blueprint Medicines Corp COMM 09627Y109 1217 15607 SH OTR 1 15607 0 0 Calithera Biosciences Inc COMM 13089P101 787 149096 SH OTR 1 149096 0 0 ChemoCentryx Inc COMM 16383L106 918 15954 SH OTR 1 15954 0 0 Compugen Ltd COMM M25722105 256 17030 SH OTR 1 17030 0 0 Constellation Pharmaceuticals Inc COMM 210373106 1024 34077 SH OTR 1 34077 0 0 Cytokinetics Inc COMM 23282W605 621 26340 SH OTR 1 26340 0 0 Eli Lilly & Co COMM 532457108 4021 24493 SH OTR 1 24493 0 0 Gilead Sciences Inc COMM 375558103 5104 66335 SH OTR 1 66335 0 0 Select Sector SPDR Tr SBI Healthcare 81369Y959 2472 24700 SH Put OTR 1 24700 0 0 Homology Medicines Inc COMM 438083107 826 54376 SH OTR 1 54376 0 0 Horizon Therapeutics PLC COMM G46188101 2314 41630 SH OTR 1 41630 0 0 Immunovant Inc COMM 45258J102 168 6900 SH OTR 1 6900 0 0 Insmed Inc COMM 457669307 2193 79643 SH OTR 1 79643 0 0 Intellia Therapeutics Inc COMM 45826J105 199 9459 SH OTR 1 9459 0 0 Intra-Cellular Therapies Inc COMM 46116X951 929 36200 SH Put OTR 1 36200 0 0 Intra-Cellular Therapies Inc COMM 46116X101 1021 39793 SH OTR 1 39793 0 0 Invesco QQQ Trust UNIT SER 1 46090E953 1213 4900 SH Put OTR 1 4900 0 0 Jazz Pharmaceuticals PLC COMM G50871105 4417 40035 SH OTR 1 40035 0 0 Kadmon Holdings Inc COMM 48283N106 1290 251920 SH OTR 1 251920 0 0 Kala Pharmaceuticals Inc COMM 483119103 876 83359 SH OTR 1 83359 0 0 Kura Oncology Inc COMM 50127T109 1637 100445 SH OTR 1 100445 0 0 Liquidia Technologies Inc COMM 53635D202 1109 131694 SH OTR 1 131694 0 0 Menlo Therapeutics Inc COMM 586858102 207 119406 SH OTR 1 119406 0 0 Merck & Co Inc COMM 58933Y105 5739 74217 SH OTR 1 74217 0 0 Mersana Therapeutics Inc COMM 59045L106 531 22681 SH OTR 1 22681 0 0 Mirati Therapeutics Inc COMM 60468T105 152 1328 SH OTR 1 1328 0 0 Mirum Pharmaceuticals Inc COMM 604749101 1735 89150 SH OTR 1 89150 0 0 MyoKardia Inc COMM 62857M105 1776 18385 SH OTR 1 18385 0 0 Novocure Ltd COMM G6674U908 486 8200 SH Call OTR 1 8200 0 0 Oric Pharmaceuticals Inc COMM 68622P109 96 2858 SH OTR 1 2858 0 0 Otonomy Inc COMM 68906L105 1028 283853 SH OTR 1 283853 0 0 PTC Therapeutics Inc COMM 69366J200 3658 72085 SH OTR 1 72085 0 0 PTC Therapeutics Inc COMM 69366J900 502 9900 SH Call OTR 1 9900 0 0 Pfizer Inc COMM 717081903 942 28800 SH Call OTR 1 28800 0 0 Protagonist Therapeutics Inc COMM 74366E102 947 53626 SH OTR 1 53626 0 0 Puma Biotechnology Inc COMM 74587V107 2055 196982 SH OTR 1 196982 0 0 Reata Pharmaceuticals Inc COMM 75615P103 335 2146 SH OTR 1 2146 0 0 Rigel Pharmaceuticals Inc COMM 766559603 102 55898 SH OTR 1 55898 0 0 SPDR Ser Tr S&P Biotech 78464A950 2765 24700 SH Put OTR 1 24700 0 0 Supernus Pharmaceuticals Inc COMM 868459108 1868 78672 SH OTR 1 78672 0 0 Syndax Pharmaceuticals Inc COMM 87164F105 227 15286 SH OTR 1 15286 0 0 TG Therapeutics Inc COMM 88322Q108 2233 114646 SH OTR 1 114646 0 0 United Therapeutics Corp COMM 91307C102 6066 50133 SH OTR 1 50133 0 0 Zymeworks Inc COMM 98985W102 1654 45848 SH OTR 1 45848 0 0 iShares Tr Russell 2000 ETF 464287955 1647 11500 SH Put OTR 1 11500 0 0 Abbvie Inc COMM 00287Y109 9899 100820 SH OTR 2 100820 0 0 Acceleron Pharma Inc COMM 00434H108 8286 86975 SH OTR 2 86975 0 0 Akebia Therapeutics Inc COMM 00972D105 3704 272718 SH OTR 2 272718 0 0 Alnylam Pharmaceuticals Inc COMM 02043Q907 8887 60000 SH Call OTR 2 60000 0 0 Amgen Inc COMM 031162950 15897 67400 SH Put OTR 2 67400 0 0 Applied Genetic Technologies Corp COMM 03820J100 2790 503538 SH OTR 2 503538 0 0 Arena Pharmaceuticals Inc COMM 040047607 351 5572 SH OTR 2 5572 0 0 Axsome Therapeutics Inc COMM 05464T104 2862 34788 SH OTR 2 34788 0 0 BioCryst Pharmaceuticals Inc COMM 09058V103 2586 542609 SH OTR 2 542609 0 0 Biomarin Pharmaceutical Inc COMM 09061G101 3104 25167 SH OTR 2 25167 0 0 Blueprint Medicines Corp COMM 09627Y109 2953 37857 SH OTR 2 37857 0 0 Calithera Biosciences Inc COMM 13089P101 2614 495126 SH OTR 2 495126 0 0 ChemoCentryx Inc COMM 16383L106 2231 38770 SH OTR 2 38770 0 0 Compugen Ltd COMM M25722105 623 41450 SH OTR 2 41450 0 0 Constellation Pharmaceuticals Inc COMM 210373106 2490 82866 SH OTR 2 82866 0 0 Cytokinetics Inc COMM 23282W605 1511 64110 SH OTR 2 64110 0 0 Eli Lilly & Co COMM 532457108 9781 59573 SH OTR 2 59573 0 0 Gilead Sciences Inc COMM 375558103 12422 161453 SH OTR 2 161453 0 0 Select Sector SPDR Tr SBI Healthcare 81369Y959 6004 60000 SH Put OTR 2 60000 0 0 Homology Medicines Inc COMM 438083107 2223 146372 SH OTR 2 146372 0 0 Horizon Therapeutics PLC COMM G46188101 5625 101208 SH OTR 2 101208 0 0 Immunovant Inc COMM 45258J102 372 15275 SH OTR 2 15275 0 0 Insmed Inc COMM 457669307 5334 193678 SH OTR 2 193678 0 0 Intellia Therapeutics Inc COMM 45826J105 483 22991 SH OTR 2 22991 0 0 Intra-Cellular Therapies Inc COMM 46116X951 2256 87900 SH Put OTR 2 87900 0 0 Intra-Cellular Therapies Inc COMM 46116X101 2484 96769 SH OTR 2 96769 0 0 Invesco QQQ Trust UNIT SER 1 46090E953 2971 12000 SH Put OTR 2 12000 0 0 Jazz Pharmaceuticals PLC COMM G50871105 10741 97343 SH OTR 2 97343 0 0 Kadmon Holdings Inc COMM 48283N106 3136 612563 SH OTR 2 612563 0 0 Kala Pharmaceuticals Inc COMM 483119103 2130 202678 SH OTR 2 202678 0 0 Kura Oncology Inc COMM 50127T109 3985 244476 SH OTR 2 244476 0 0 Liquidia Technologies Inc COMM 53635D202 2694 320001 SH OTR 2 320001 0 0 Menlo Therapeutics Inc COMM 586858102 502 290138 SH OTR 2 290138 0 0 Merck & Co Inc COMM 58933Y105 13918 179976 SH OTR 2 179976 0 0 Mersana Therapeutics Inc COMM 59045L106 1289 55101 SH OTR 2 55101 0 0 Mirati Therapeutics Inc COMM 60468T105 369 3230 SH OTR 2 3230 0 0 Mirum Pharmaceuticals Inc COMM 604749101 4216 216669 SH OTR 2 216669 0 0 MyoKardia Inc COMM 62857M105 4309 44599 SH OTR 2 44599 0 0 Novocure Ltd COMM G6674U908 1186 20000 SH Call OTR 2 20000 0 0 Oric Pharmaceuticals Inc COMM 68622P109 234 6942 SH OTR 2 6942 0 0 Otonomy Inc COMM 68906L105 2278 629404 SH OTR 2 629404 0 0 PTC Therapeutics Inc COMM 69366J200 8871 174827 SH OTR 2 174827 0 0 PTC Therapeutics Inc COMM 69366J900 1218 24000 SH Call OTR 2 24000 0 0 Pfizer Inc COMM 717081903 2289 70000 SH Call OTR 2 70000 0 0 Protagonist Therapeutics Inc COMM 74366E102 2303 130418 SH OTR 2 130418 0 0 Puma Biotechnology Inc COMM 74587V107 5009 480278 SH OTR 2 480278 0 0 Reata Pharmaceuticals Inc COMM 75615P103 813 5209 SH OTR 2 5209 0 0 Rigel Pharmaceuticals Inc COMM 766559603 249 135969 SH OTR 2 135969 0 0 SPDR Ser Tr S&P Biotech 78464A950 6717 60000 SH Put OTR 2 60000 0 0 Supernus Pharmaceuticals Inc COMM 868459108 4532 190842 SH OTR 2 190842 0 0 Syndax Pharmaceuticals Inc COMM 87164F105 535 36095 SH OTR 2 36095 0 0 TG Therapeutics Inc COMM 88322Q108 5423 278370 SH OTR 2 278370 0 0 United Therapeutics Corp COMM 91307C102 14738 121805 SH OTR 2 121805 0 0 Zymeworks Inc COMM 98985W102 4764 132071 SH OTR 2 132071 0 0 iShares Tr Russell 2000 ETF 464287955 4009 28000 SH Put OTR 2 28000 0 0