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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2022
Mar. 31, 2022
Jun. 30, 2021
Mar. 31, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:              
Net loss $ (82,470) $ (81,423) $ (69,592) $ (74,930) $ (163,893) $ (144,522)  
Adjustments to reconcile net loss to net cash used in operating activities:              
Depreciation and amortization         3,052 2,908  
Amortization (accretion) of premium (discount) on marketable securities         88 112  
Non-cash interest expense         1,541 476  
Amortization of operating lease right-of-use assets         1,518 1,301  
Stock-based compensation         38,984 41,184  
Changes in operating assets and liabilities:              
Accounts receivables         (965) (2,044)  
Inventories         (6,806) (6,841)  
Prepaid expenses and other assets, current         2,977 (7,121)  
Other assets, non-current         (394) 0  
Accounts payable         (6,844) (9,730)  
Accrued liabilities         13,971 7,683  
Accrued compensation         (2,525) (4,655)  
Operating lease liabilities         (2,735) (2,328)  
Other liabilities, noncurrent         5,870 0  
Net cash used in operating activities         (116,161) (123,577)  
CASH FLOWS FROM INVESTING ACTIVITIES:              
Purchases of property and equipment         (636) (1,920)  
Purchases of marketable securities         (386,025) 0  
Maturities of marketable securities         29,500 47,670  
Net cash provided by (used in) investing activities         (357,161) 45,750  
CASH FLOWS FROM FINANCING ACTIVITIES:              
Proceeds from issuance of common stock in settlement of employee stock purchase plan and exercise of stock options         2,799 4,083  
Proceeds from issuance of common stock upon at-the-market offering, net of issuance cost         48,495 0  
Taxes paid related to net share settlement of equity awards         (1,095) (1,962)  
Payments of debt issuance costs         0 (49)  
Net cash provided by financing activities         50,199 2,072  
Effect of exchange rate changes on cash and cash equivalents         (446) 259  
Net decrease in cash, cash equivalents and restricted cash         (423,569) (75,496)  
Cash, cash equivalents and restricted cash at beginning of period   $ 687,153   $ 497,202 687,153 497,202 $ 497,202
Cash, cash equivalents and restricted cash at end of period 263,584   421,706   263,584 421,706 687,153
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:              
Cash paid for interest         14,511 6,788  
Cash paid for income taxes         80 0  
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION:              
Accrued issuance costs         0 (26)  
Accrued purchase of property and equipment         7 (36)  
RECONCILIATION OF CASH, CASH EQUIVALENTS, AND RESTRICTED CASH TO THE CONDENSED CONSOLIDATED BALANCE SHEETS              
Cash and cash equivalents 261,152   419,311   261,152 419,311 $ 684,717
Restricted cash 2,432   2,395   2,432 2,395  
Total cash and cash equivalents and restricted cash $ 263,584   $ 421,706   $ 263,584 $ 421,706