Stock-Based Compensation - Summary of RSU Activity Granted to Employees with Service-Based Vesting (Detail) - 2017 Inducement Plan and 2015 Plan [Member] - RSU [Member]	6 Months Ended
	Jun. 30, 2022 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Units, Beginning Balance | shares	2,986,269
RSUs granted, Number of RSUs | shares	1,886,774
RSUs vested, Number of RSUs | shares	(482,023)
RSUs forfeited, Number of RSUs | shares	(300,044)
Number of Units, Ending Balance | shares	4,090,976
Weighted-Average Grant Date Fair Value, Beginning Balance | $ / shares	$ 45.37
RSUs granted, Weighted-Average Grant Date Fair Value | $ / shares	29.83
RSUs vested, Weighted-Average Grant Date Fair Value | $ / shares	51.13
RSUs forfeited, Weighted-Average Grant Date Fair Value | $ / shares	40.03
Weighted-Average Grant Date Fair Value, Ending Balance | $ / shares	$ 37.92