X0306 4 2022-10-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001913961 Habibizad Nazila C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Common Stock 2022-09-29 5 G 0 E 3500 0.00 D 38123 D Common Stock 2022-10-01 4 M 0 1375 A 39498 D Common Stock 2022-10-01 4 M 0 182 A 39680 D Restricted Stock Units 2022-10-01 4 M 0 1375 0.00 D Common Stock 1375 2750 D Restricted Stock Units 2022-10-01 4 M 0 182 0.00 D Common Stock 182 548 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. The shares of Common Stock underlying the original grant of 11,000 RSUs vest in eight semi-annual installments after October 1, 2019 through October 1, 2023, subject to the Reporting Person's continuous service with the Issuer through each vesting date, and have no expiration date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the original grant of 1,461 RSUs vest in eight semi-annual installments after April 1, 2020 through April 1, 2024, subject to the Reporting Person's continuous service with the Issuer through each vesting date, and have no expiration date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Executive Vice President, Operations /s/ Miguel Carrillo, Attorney-in-Fact 2022-10-04