X0306 4 2022-09-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001823899 Krehlik Carrie C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Human Resources Officer Common Stock 2022-09-01 4 M 0 8060 A 8060 D Common Stock 2022-09-01 4 M 0 2208 A 10268 D Common Stock 2022-09-01 4 F 0 3552 68.15 D 6716 D Restricted Stock Units 2022-09-01 4 M 0 8060 0.00 D Common Stock 8060 24180 D Restricted Stock Units 2022-09-01 4 M 0 2208 0.00 D Common Stock 2208 15460 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents the number of shares of the Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 10,268 shares of Common Stock underlying the Reporting Person's RSUs. The RSUs vest with respect to 25% of the underlying shares on September 1, 2022 and in 6 semi-annual installments thereafter, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from March 1, 2022, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Miguel Carrillo, Attorney-in-Fact 2022-09-06