X0306 4 2022-06-21 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001574286 Pizzo Philip A. C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2022-06-21 4 S 0 1260 27.2517 D 9112 D This sale was executed pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 25, 2022 to cover the Reporting Person's tax obligations in connection with the vesting of 3,600 shares of Common Stock underlying the Reporting Person's RSUs as previously reported on the Form 4 filed by the Reporting Person on June 16, 2022. Represents the weighted average sale price of the shares sold ranging from $26.80 to $27.69 per share, inclusive. The Reporting Person will provide, upon request by the Issuer, a security holder of the Issuer, or the staff of the Securities and Exchange Commission, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Miguel Carrillo, Attorney-in-Fact 2022-06-22