X0306 4 2022-06-14 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001256964 PIERCE GLENN C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2022-06-14 4 M 0 3600 A 26437 D Restricted Stock Units 2022-06-14 4 M 0 3600 0.00 D 2022-06-14 Common Stock 3600 0 D Stock Option (Right to Buy) 22.30 2022-06-14 4 A 0 5600 0.00 A 2032-06-13 Common Stock 5600 5600 D Restricted Stock Units 2022-06-14 4 A 0 3600 0.00 A Common Stock 3600 3600 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested in a single installment on June 14, 2022. The shares subject to this option shall vest and become exercisable in equal monthly installments over a period of 12 months following June 14, 2022 for 11 months and the remaining 1/12th on the earlier of (i) June 14, 2023 or (ii) the Issuer's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Issuer's Board of Directors. This option is subject to full acceleration of vesting with respect to all then-unvested shares upon the consummation of a Sale Event (as defined in the Issuer's 2015 Stock Option and Incentive Plan, as amended). The shares of Common Stock underlying the RSUs vest in a single installment on the earlier of (i) June 14, 2023 or (ii) the Issuer's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Issuer's Board of Directors. The shares of Common Stock underlying the RSUs are subject to full acceleration of vesting with respect to all then-unvested shares upon the consummation of a Sale Event (as defined in the Issuer's 2015 Stock Option and Incentive Plan, as amended). /s/ Miguel Carrillo, Attorney-in-Fact 2022-06-16