X0306 4 2022-02-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001188919 LOVE TED W C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 1 1 0 0 President and CEO Common Stock 2022-02-01 4 M 0 29955 A 799308 D Common Stock 2022-02-01 4 F 0 10531 29.33 D 788777 D Common Stock 102000 I By Trust 1 Common Stock 102000 I By Trust 2 Common Stock 102000 I By Trust 3 Common Stock 2500 I By Daughter Common Stock 2500 I By Daughter Restricted Stock Units 2022-02-01 4 M 0 9750 0.00 D Common Stock 9750 0 D Restricted Stock Units 2022-02-01 4 M 0 11250 0.00 D Common Stock 11250 22500 D Restricted Stock Units 2022-02-01 4 M 0 8955 0.00 D Common Stock 8955 35820 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. Corrected balance; see Form 4/A filed on January 6, 2022. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 29,955 shares of Common Stock underlying the Reporting Person's RSUs. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2018, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Miguel Carrillo, Attorney-in-Fact 2022-02-03