X0306 4/A 2021-08-01 2021-08-03 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001188919 LOVE TED W C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 1 1 0 0 President and CEO Common Stock 2021-08-01 4 M 0 29955 A 804266 D Common Stock 2021-08-01 4 F 0 14853 27.33 D 789413 D Common Stock 102000 I By Trust 1 Common Stock 102000 I By Trust 2 Common Stock 102000 I By Trust 3 Common Stock 2500 I By Daughter Common Stock 2500 I By Daughter Restricted Stock Units 2021-08-01 4 M 0 9750 0.00 D Common Stock 9750 9750 D Restricted Stock Units 2021-08-01 4 M 0 11250 0.00 D Common Stock 11250 33750 D Restricted Stock Units 2021-08-01 4 M 0 8955 0.00 D Common Stock 8955 44775 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 29,955 shares of Common Stock underlying the Reporting Person's RSUs. The shares of Common Stock underlying the RSUs vested in 8 equal semi-annual installments over 4 years from February 1, 2017. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2018, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. This amended Form 4 is being filed solely to attach a Power of Attorney granted by the Reporting Person which was not previously attached. All other information in the original Form 4 remains the same. The original Form 4 was timely filed on August 3, 2021. Exhibit 24 - Power of Attorney /s/ Miguel Carrillo, as Attorney-in-Fact 2021-09-24