<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-03-17</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001629137</issuerCik>
        <issuerName>Global Blood Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>GBT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001851895</rptOwnerCik>
            <rptOwnerName>Thompson Alexis A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O GLOBAL BLOOD THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>181 OYSTER POINT BLVD.</rptOwnerStreet2>
            <rptOwnerCity>SOUTH SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>EXHIBIT 24 - POWER OF ATTORNEY</remarks>

    <ownerSignature>
        <signatureName>/s/   Tricia Suvari, Attorney-in-Fact</signatureName>
        <signatureDate>2021-03-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
