X0306 4 2020-08-05 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001784038 Fink Eric C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Human Resources Officer Common Stock 2020-08-05 4 S 0 1504 69.3185 D 950 D Common Stock 2020-08-05 4 S 0 950 70.1008 D 0 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 12, 2020. Represents the weighted average sale price of the shares sold ranging from $68.855 to $69.75 per share, inclusive. The Reporting Person will provide, upon request by the Issuer, a security holder of the Issuer, or the staff of the Securities and Exchange Commission, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Represents the weighted average sale price of the shares sold ranging from $69.98 to $70.30 per share, inclusive. The Reporting Person will provide, upon request by the Issuer, a security holder of the Issuer, or the staff of the Securities and Exchange Commission, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/Tricia Suvari, as Attorney-in-Fact 2020-08-07