X0306 4 2020-08-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001188919 LOVE TED W C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 1 1 0 0 See Remarks Common Stock 2020-06-12 5 G 0 E 306000 0.00 D 728633 D Common Stock 2020-08-01 4 M 0 42017 A 770650 D Common Stock 2020-08-01 4 F 0 20834 67.48 D 749816 D Common Stock 102000 I By Trust 1 Common Stock 102000 I By Trust 2 Common Stock 102000 I By Trust 3 Common Stock 2500 I By Daughter Common Stock 2500 I By Daughter Restricted Stock Units 2020-08-01 4 M 0 12062 0.00 D Common Stock 12062 12063 D Restricted Stock Units 2020-08-01 4 M 0 9750 0.00 D Common Stock 9750 29250 D Restricted Stock Units 2020-08-01 4 M 0 11250 0.00 D Common Stock 11250 56250 D Restricted Stock Units 2020-08-01 4 M 0 8955 0.00 D Common Stock 8955 62685 D On June 12, 2020, the Reporting Person transferred 102,000 shares by gift to each of three trusts for the benefit of the Reporting Person's daughters. Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 42,017 shares of Common Stock underlying the Reporting Person's RSUs. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2018, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Title: President and Chief Executive Officer /s/ Tricia Suvari, as Attorney-in-Fact 2020-08-04