X0306 4 2020-05-12 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001190270 PERRY MARK L C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2020-05-12 4 M 0 15000 20.00 A 41428 D Common Stock 2020-05-12 4 M 0 8600 20.00 A 50028 D Common Stock 2020-05-12 4 M 0 15000 18.85 A 65028 D Common Stock 2020-05-12 4 M 0 15000 28.45 A 80028 D Common Stock 2020-05-12 4 S 0 2633 74.0088 D 77395 D Common Stock 2020-05-12 4 S 0 1350 75.4322 D 76045 D Common Stock 2020-05-12 4 S 0 600 76.2842 D 75445 D Common Stock 2020-05-12 4 S 0 13024 77.7133 D 62421 D Common Stock 2020-05-12 4 S 0 34698 78.6481 D 27723 D Common Stock 2020-05-12 4 S 0 1295 79.1673 D 26428 D Stock Option (Right to Buy) 20.00 2020-05-12 4 M 0 15000 0.00 A 2025-08-10 Common Stock 15000 0 D Stock Option (Right to Buy) 20.00 2020-05-12 4 M 0 8600 0.00 A 2025-08-10 Common Stock 8600 0 D Stock Option (Right to Buy) 18.85 2020-05-12 4 M 0 15000 0.00 A 2026-06-15 Common Stock 15000 0 D Stock Option (Right to Buy) 28.45 2020-05-12 4 M 0 15000 0.00 A 2027-06-19 Common Stock 15000 0 D Represents weighted average sales price. The shares were sold at prices ranging from $73.90 to $74.11. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. Represents weighted average sales price. The shares were sold at prices ranging from $75.13 to $75.88. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. Represents weighted average sales price. The shares were sold at prices ranging from $76.15 to $76.44. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. Represents weighted average sales price. The shares were sold at prices ranging from $77.16 to $78.01. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. Represents weighted average sales price. The shares were sold at prices ranging from $78.16 to $79.1450. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. Represents weighted average sales price. The shares were sold at prices ranging from $79.16 to $79.18. The Reporting Person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. The shares subject to the option are fully vested. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2020-05-13