X0306 4 2020-03-05 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001789673 Lehrer-Graiwer Joshua C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Common Stock 2020-03-05 4 S 0 1138 65.30 D 2595 D Common Stock 2020-03-09 4 M 0 938 19.89 A 3533 D Common Stock 2020-03-09 4 S 0 938 59.90 D 2595 D Stock Option (Right to Buy) 19.89 2020-03-09 4 M 0 938 0.00 D 2026-09-07 Common Stock 938 1875 D This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person. Represents the weighted average sale price of the shares sold ranging from $59.80 to $60.00 per share, inclusive. The Reporting Person will provide, upon request by the Issuer, a security holder of the Issuer, or the staff of the Securities and Exchange Commission, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The shares of Common Stock underlying the option shall vest in 16 equal quarterly installments over 4 years from September 8, 2016, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/Tricia Suvari , as Attorney-in-Fact 2020-03-09