X0306 4 2020-01-27 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001789673 Lehrer-Graiwer Joshua C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Common Stock 2020-01-27 4 M 0 781 27.90 A 2797 D Common Stock 2020-01-27 4 S 0 781 71.15 D 2016 D Stock Option (Right to Buy) 27.90 2020-01-27 4 M 0 781 0.00 D 2027-07-25 Common Stock 781 4688 D This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person. The shares of Common Stock underlying the option shall vest in 16 equal quarterly installments over 4 years from July 26, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/Lesley Ann Calhoun, as Attorney-in-Fact 2020-01-29