X0306 4 2019-12-13 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001789673 Lehrer-Graiwer Joshua C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Common Stock 2019-12-13 4 M 0 4000 A 4000 D Common Stock 2019-12-13 4 F 0 1984 76.88 D 2016 D Restricted Stock Units 2019-12-13 4 M 0 4000 0.00 D Common Stock 4000 0 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 4,000 shares of Common Stock underlying the Reporting Person's RSUs. On August 11, 2017, the Reporting Person was granted 12,000 RSUs, which vest in installments upon the achievement of specified market capitalization milestones of the Issuer on or before December 31, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting milestone. On December 13, 2019, the final performance milestone was achieved, resulting in the vesting of the remaining 4,000 shares of Common Stock underlying the RSU grant. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2019-12-17