X0306 4 2019-11-25 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001789673 Lehrer-Graiwer Joshua C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Common Stock 2019-11-25 4 M 0 312 12.95 A 312 D Common Stock 2019-11-25 4 S 0 312 60.00 D 0 D Common Stock 2019-11-25 4 M 0 1108 19.89 A 1108 D Common Stock 2019-11-25 4 S 0 1108 60.00 D 0 D Common Stock 2019-11-25 4 M 0 3515 27.90 A 3515 D Common Stock 2019-11-25 4 S 0 3515 60.00 D 0 D Common Stock 2019-11-25 4 M 0 447 20.00 A 447 D Common Stock 2019-11-25 4 S 0 447 60.00 D 0 D Common Stock 2019-11-25 4 M 0 298 19.89 A 298 D Common Stock 2019-11-25 4 S 0 298 60.00 D 0 D Common Stock 2019-11-25 4 M 0 4594 26.90 A 4594 D Common Stock 2019-11-25 4 S 0 4594 60.00 D 0 D Common Stock 2019-11-25 4 M 0 656 26.90 A 656 D Common Stock 2019-11-25 4 S 0 656 60.00 D 0 D Common Stock 2019-11-26 4 M 0 11593 59.60 A 11593 D Common Stock 2019-11-26 4 S 0 11593 67.19 D 0 D Stock Option (Right to Buy) 12.95 2019-11-25 4 M 0 312 0.00 D 2026-02-08 Common Stock 312 625 D Stock Option (Right to Buy) 19.89 2019-11-25 4 M 0 1108 0.00 D 2026-09-07 Common Stock 1108 4048 D Stock Option (Right to Buy) 27.90 2019-11-25 4 M 0 3515 0.00 D 2027-07-25 Common Stock 3515 5469 D Stock Option (Right to Buy) 20.00 2019-11-25 4 M 0 447 0.00 D 2025-08-10 Common Stock 447 0 D Stock Option (Right to Buy) 19.89 2019-11-25 4 M 0 298 0.00 D 2026-09-07 Common Stock 298 3750 D Stock Option (Right to Buy) 26.90 2019-11-25 4 M 0 4594 0.00 D 2027-02-16 Common Stock 4594 7219 D Stock Option (Right to Buy) 26.90 2019-11-25 4 M 0 656 0.00 D 2027-02-16 Common Stock 656 6563 D Stock Option (Right to Buy) 59.60 2019-11-26 4 M 0 11593 0.00 D 2028-01-31 Common Stock 11593 14907 D This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person. The shares of Common Stock underlying this option shall vest in 16 equal quarterly installments over 4 years from February 9, 2016, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the option shall vest in 16 equal quarterly installments over 4 years from September 8, 2016, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying this option shall vest in 16 equal quarterly installments over 4 years from July 26, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying this option are fully vested. The shares of Common Stock underlying this option shall vest in 16 equal quarterly installments over 4 years from February 17, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the option shall vest in 16 equal quarterly installments over 4 years from February 1, 2018, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2019-11-27