X0306 4 2018-12-19 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001574579 Svoronos Dawn C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Option (Right to Buy) 38.68 2018-12-19 4 A 0 30000 0.00 A 2028-12-18 Common Stock 30000 30000 D The shares vest and become exercisable in 36 equal monthly installments with the first installment on January 19, 2019, subject to the recipient's continued service on the Issuer's Board of Directors. This option is subject to accelerated vesting upon a change of control of the Issuer. /s/ Lesley Calhoun, as Attorney-in-Fact 2018-12-21