X0306 4 2018-11-27 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001405253 Farrow Jeffrey S C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Financial Officer Common Stock 2018-11-27 4 M 0 3048 16.40 A 15555 D Stock Option (Right to Buy) 16.40 2018-11-27 4 M 0 3048 0.00 D 2027-01-16 Common Stock 3048 33952 D The shares underlying the option vest in equal quarterly installments over 16 quarters from January 17, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2018-11-28