X0306 4 2018-08-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001405253 Farrow Jeffrey S C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Financial Officer Common Stock 2018-08-01 4 M 0 5937 A 14907 D Common Stock 2018-08-01 4 F 0 2400 43.15 D 12507 D Restricted Stock Units 2018-08-01 4 M 0 3062 0.00 D Common Stock 3062 15313 D Restricted Stock Units 2018-08-01 4 M 0 2875 0.00 D Common Stock 2875 20125 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 3,250 shares of Common Stock underlying the Reporting Person's RSUs. The RSUs vest in eight equal semi-annual installments after February 1, 2017 until fully vested on February 1, 2021, subject to the Reporting Person's continuous service with the Issuer. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason upon a change of control of the Issuer. The RSUs vest in eight equal semi-annual installments after February 1, 2018 until fully vested on February 1, 2022, subject to the Reporting Person's continuous service with the Issuer. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason upon a change of control of the Issuer. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2018-08-03