X0206 3 2018-03-13 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001733883 JOHNSON DAVID LEE C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Commercial Officer Restricted Stock Units 0.00 Common Stock 35000 D Stock Option (Right to Buy) 54.05 2028-03-11 Common Stock 55000 D Each restricted stock unit represents a contingent right to receive one share of GBT common stock. The Restricted Stock Units shall vest with respect to 1/4th of the underlying shares on April 1, 2019. Thereafter, 1/6th of the remaining underlying shares shall vest on a semi-annual basis (every six months) until fully vested on April 1, 2022, subject to the Reporting Person's continuous service with the Issuer. The Restricted Stock Units are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The Stock Option becomes exercisable with respect to 1/4th of the underlying shares on March 12, 2019 and with respect to an additional 1/12th of the underlying shares each quarter thereafter until fully vested on March 12, 2022, subject to the Reporting Person's continuous service with the Issuer. The Stock Option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ David Lee Johnson 2018-03-14