X0306 5 2017-12-31 0 0 1 0001629137 Global Blood Therapeutics, Inc. GBT 0001730866 Calhoun Lesley Ann C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Common Stock 2017-08-02 4 S 0 1552 27.23 D 0 D Common Stock 2017-09-01 4 M 0 300 A 300 D Common Stock 2017-09-01 4 S 0 113 30.30 D 187 D Stock Option (Right to Buy) 29.75 2017-03-01 4 A 0 3600 0.00 A 2026-02-28 Common Stock 3600 3600 D Restricted Stock Units 2017-03-01 4 A 0 2400 A Common Stock 2400 2400 D Restricted Stock Units 2017-09-01 4 M 0 300 D Common Stock 300 2100 D Includes 1,552 shares acquired under the Issuer's Employee Stock Purchase Plan on July 31, 2017 in a transaction exempt under Rule 16b-3. Each restricted stock unit represents a contingent right to receive one share of GBT common stock. The Stock Option becomes exercisable in sixteen equal quarterly installments after March 1, 2017 until fully vested on March 1, 2021, subject to the Reporting Person's continuous service with the Issuer. The Stock Option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The Restricted Stock Units vest in eight semiannual installments after March 1, 2017 until fully vested on March 1, 2021, subject to the Reporting Person's continuous service with the Issuer. The Restricted Stock Units are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Vice President, Finance and Principal Accounting Officer /s/ Lesley Ann Calhoun 2018-02-13