X0306 4 2018-01-24 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001650126 Choi Jung C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Common Stock 2018-01-24 4 M 0 2000 A 136778 D Common Stock 2018-01-24 4 F 0 686 58.15 D 136092 D Common Stock 25000 I By Trust Restricted Stock Units 2018-01-24 4 M 0 2000 0.00 D Common Stock 2000 11000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 2,000 shares of Common Stock underlying the Reporting Person's RSUs. On August 11, 2017, the Reporting Person was granted 15,000 RSUs, which vest in installments upon the achievement of specified market capitalization milestones of the Issuer on or before December 31, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting milestone. On January 24, 2018, one of the performance milestones was achieved, resulting in the vesting of 2,000 shares of Common Stock underlying the RSU grant. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Chief Business and Strategy Officer /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2018-01-26