X0306 4 2017-08-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001650131 Radovich Peter C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Restricted Stock Units 2017-08-11 4 A 0 12000 0.00 A Common Stock 12000 12000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. The RSUs vest in installments upon the achievement of specified market capitalization milestones of the Issuer on or before December 31, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting milestone. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Senior Vice President, Operations /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2017-08-15