X0306 4 2017-08-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001188919 LOVE TED W C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 1 1 0 0 See Remarks Common Stock 2017-08-11 4 D 0 124106 3.395 D 1027850 D Common Stock 2500 I By daughter Common Stock 2500 I By daughter Restricted Stock Units 2017-08-11 4 A 0 262500 0.00 D Common Stock 262500 262500 D Represents unvested shares of Common Stock repurchased by the Issuer at the original purchase price paid by the Reporting Person because the conditions for the vesting of such shares were not achieved within the timeframes specified for such vesting. Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. The RSUs vest in installments upon the achievement of specified market capitalization milestones of the Issuer on or before December 31, 2019, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting milestone. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Chief Executive Officer and President /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2017-08-14