X0306 4 2017-08-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001650158 Sham Hing C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Common Stock 2017-08-01 4 M 0 3000 A 61204 D Common Stock 2017-08-01 4 F 0 1128 25.10 D 60076 D Common Stock 2017-08-02 4 M 0 21428 0.49 A 81504 D Restricted Stock Units 2017-08-01 4 M 0 3000 0.00 D Common Stock 3000 21000 D Stock Option (right to buy) 0.49 2017-08-02 4 M 0 21428 0.00 D 2024-09-09 Common Stock 21428 21429 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. Represents number of shares of Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 3,000 shares of Common Stock underlying the Reporting Person's RSUs. On January 17, 2017, the Reporting Person was granted 24,000 RSUs, which vest in equal semi-annual installments over 4 years from February 1, 2017, subject to the Reporting Person's continued employment with the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The option vested and became exercisable with respect to 25% of the shares subject to the option on July 28, 2015, and the remaining shares subject to this option vest and become exercisable in 12 equal quarterly installments thereafter. Senior Vice President, Chemistry Lesley Ann Calhoun, as Attorney-in-Fact 2017-08-03