X0306 4 2017-07-25 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001053466 PATRICK DEVAL L C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2017-07-25 4 M 0 12053 3.40 A 12053 D Common Stock 2017-07-25 4 M 0 15000 18.85 A 27053 D Common Stock 2017-07-25 4 S 0 27053 29.69 D 0 D Employee Stock Option (right to buy) 3.40 2017-07-25 4 M 0 12053 0.00 D 2025-04-08 Common Stock 12053 9375 D Employee Stock Option (right to buy) 18.85 2017-07-25 4 M 0 15000 0.00 D 2026-06-15 Common Stock 15000 0 D 25% of the shares subject to this option vested and became exercisable on April 8, 2016, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. The shares vested and became exercisable in 12 equal monthly installments, with the first installment on July 16, 2016, subject to the recipient's continued service on the Issuer's Board of Directors. This option was subject to accelerated vesting upon a change of control of the Issuer. /s/ Matt Krause, as Attorney-in-Fact 2017-07-27