X0306 5 2016-12-31 0 0 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001192591 HOMCY CHARLES J C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2016-11-03 5 J 0 14611 0.00 A 227296 D Common Stock 2016-12-16 5 J 0 10432 0.00 A 237728 D Common Stock 1600 I Trust Includes 14,611 shares received by the Reporting Person in a distribution-in-kind by Third Rock Ventures II, L.P. ("TRV II") on November 3, 2016, which distribution was made in accordance with the exemption afforded by Rule 16a-13 of the Securities Exchange Act of 1934, as amended, as reported on Form 4s filed by the Reporting Person on November 7, 2016 and November 16, 2016. This report is being filed with respect to this transaction solely to correct the total number of shares held by the Reporting Person immediately following the transaction. Includes 10,432 shares received by the Reporting Person in a distribution-in-kind by TRV II on December 16, 2016, which distribution was made in accordance with the exemption afforded by Rule 16a-13 of the Securities Exchange Act of 1934, as amended. /s/ Matt Krause as Attorney-in-Fact for the Reporting Person 2017-02-14