X0306 4 2017-01-17 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001405253 Farrow Jeffrey S C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Financial Officer Restricted Stock Units 2017-01-17 4 A 0 24500 0.00 A Common Stock 24500 24500 D Stock Option (right to buy) 16.40 2017-01-17 4 A 0 37000 0.00 A 2027-01-16 Common Stock 37000 37000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares underlying the option vest in equal quarterly installments over 16 quarters from January 17, 2017, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Exhibit List: Exhibit 24.1 - Power of Attorney /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2017-01-18