X0306 4 2016-11-14 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001192591 HOMCY CHARLES J C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2016-11-14 4 S 0 0 0.00 D 0 I See Footnote Common Stock 2016-11-14 4 S 0 0 0.00 D 0 I See Footnote Common Stock 14611 D The reporting person is a partner of Third Rock Ventures GP II, L.P., which is the general partner of Third Rock Ventures II, L.P. ("TRV II"). The reporting person disclaims beneficial ownership over the shares held by TRV II, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares. The reporting person is a partner of Third Rock Ventures GP III, L.P., which is the general partner of Third Rock Ventures III, L.P. ("TRV III"). The reporting person disclaims beneficial ownership over the shares held by TRV III, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares. Includes 14,611 shares received by the Reporting Person in a distributions-in-kind by TRV II on November 3, 2016, which distribution was made in accordance with the exemption afforded by Rule 16a-13 of the Securities Exchange Act of 1934, as amended. /s/ Matt Krause, attorney-in-fact 2016-11-16