X0306 4 2016-10-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001238408 SUVARI TRICIA BORGA C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Legal Officer Employee Stock Option (Right to Buy) 18.25 2016-10-11 4 A 0 100000 0.00 A 2026-10-10 Common Stock 100000 100000 D 25% of the shares subject to this option shall vest and become exercisable on October 11, 2017, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Tricia Borga Suvari 2016-10-12