X0306 4 2016-09-29 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001464907 Ramos Eleanor C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Employee Stock Option (Right to Buy) 3.40 2016-09-29 4 A 0 9286 0.00 A 2016-09-29 2025-04-08 Common Stock 9286 9286 D On April 9, 2015, the reporting person was granted an option to purchase 37,142 shares of Common Stock under the issuer's 2012 Stock Option and Grant Plan, the vesting of which was subject to various conditions (other than the passage of time and continued employment) that were not tied to the market price of the issuer's securities. On September 29, 2016, one of the conditions was deemed to be achieved, resulting in the vesting and exercisability of 9,286 of the shares underlying such option. /s/ Matt Krause, as Attorney-in-Fact 2016-10-03