X0206 3 2016-04-04 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001405253 Farrow Jeffrey S C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Financial Officer Employee Stock Option (Right to Buy) 14.96 2026-02-23 Common Stock 120000 D 25% of the shares subject to this option shall vest and become exercisable on April 4, 2017, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. Exhibit List: Exhibit 24.1 - Power of Attorney /s/ John Schembri, attorney-in-fact 2016-04-04