X0206 3 2015-08-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001375857 Schembri John C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Stock Option (Right to Buy) 0.32 2024-01-21 Common Stock 70000 D Stock Option (Right to Buy) 3.40 2025-04-08 Common Stock 47142 D 25% of the shares subject to this option shall vest and become exercisable on January 16, 2015, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. The shares subject to this option shall vest and become exercisable in 16 equal quarterly installments, with the first installment on July 9, 2015. Vice President, Finance and Administration and Corporate Secretary Exhibit List: Exhibit 24.1 - Power of Attorney /s/ John Schembri 2015-08-11