X0206 3 2015-08-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001650158 Sham Hing C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 See Remarks Common Stock 9285 D Stock Option (Right to Buy) 0.49 2024-09-09 Common Stock 85714 D Stock Option (Right to Buy) 3.40 2025-04-08 Common Stock 65000 D These shares of Common stock are subject to the Issuer's right of repurchase, which lapses in 16 equal quarterly installments, with the first installment on July 9, 2015. 25% of the shares subject to this option shall vest and become exercisable on July 28, 2015, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. The shares subject to this option shall vest and become exercisable in 16 equal quarterly installments, with the first installment on July 9, 2015. Senior Vice President, Chemistry Exhibit List: Exhibit 24.1 - Power of Attorney /s/ John Schembri, attorney-in-fact 2015-08-11