X0206 3 2015-08-11 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001464907 Ramos Eleanor C/O GLOBAL BLOOD THERAPEUTICS, INC. 400 EAST JAMIE COURT, SUITE 101 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Stock Option (Right to Buy) 0.49 2024-06-10 Common Stock 142857 D Stock Option (Right to Buy) 3.40 2025-04-08 Common Stock 77142 D 25% of the shares subject to this option shall vest and become exercisable on May 12, 2015, and the remaining shares subject to this option shall vest and become exercisable in 12 equal quarterly installments thereafter. The share subject to this option shall vest and become exercisable in 16 equal quarterly installments, with the first installment on July 9, 2015. Exhibit List: Exhibit 24.1 - Power of Attorney /s/ John Schembri, attorney-in-fact 2015-08-11