<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-09-24</periodOfReport>

    <issuer>
        <issuerCik>0001628945</issuerCik>
        <issuerName>Cue Health Inc.</issuerName>
        <issuerTradingSymbol>HLTH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001504475</rptOwnerCik>
            <rptOwnerName>Bradford K Joanne</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CUE HEALTH INC.</rptOwnerStreet1>
            <rptOwnerStreet2>4980 CARROLL CANYON RD. SUITE 100</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2021-09-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>18750</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>18750</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Grant of restricted stock units (&quot;RSUs&quot;) under the Issuer's 2021 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of the Issuer's common stock. The vesting commencement date is September 23, 2021 (the &quot;VCD&quot;). Subject to the reporting person's continued service as a director with the Issuer, the RSUs will vest as to 34% of the initial grant on the first anniversary of the VCD and as to an additional 33% at the end of each successive 12-month period following the first anniversary of the VCD, until the third anniversary of the VCD.</footnote>
        <footnote id="F2">Includes 18,750 unvested RSUs.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Erica Palsis, Attorney-in-Fact for Joanne Bradford</signatureName>
        <signatureDate>2021-09-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
