Additional amount to be drawn under term loan facility.

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Aggregate amount to be drawn under term loan facility.

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No definition available.

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Debt instrument additional amount drawing date latest.

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Debt instrument drawing date earliest.

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Debt instrument drawing date latest.

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- Definition

Percentage of aggregate amount of term loan advances funded under loan agreement.

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No definition available.

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Percentage of aggregate amount of term loans drawn.

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No definition available.

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- Definition

Exercise price per share or per unit of warrants or rights outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(4))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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- Definition

Percentage points added to the reference rate to compute the variable rate on the debt instrument.

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No definition available.

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- Definition

Face (par) amount of debt instrument at time of issuance.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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- Definition

Amount of the fee that accompanies borrowing money under the debt instrument.

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- Definition

Contractual interest rate for funds borrowed, under the debt agreement.

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- Definition

Description of the interest rate as being fixed or variable, and, if variable, identification of the index or rate on which the interest rate is based and the number of points or percentage added to that index or rate to set the rate, and other pertinent information, such as frequency of rate resets.

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- Definition

Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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- Definition

Description of the payment terms of the debt instrument (for example, whether periodic payments include principal and frequency of payments) and discussion about any contingencies associated with the payment.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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- Definition

A general description of the nature of the existing leasing arrangements of a lessee for all operating leases including, but not limited to: (1) rental escalation clauses; (2) renewal or purchase options; (3) guarantees or indemnities, if any, (4) restrictions imposed by lease arrangements; (5) unusual provisions or conditions; (6) contingent rentals, if any; and (7) lease expiration dates.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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Date which lease or group of leases is set to expire, in CCYY-MM-DD format.

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No definition available.

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- Definition

Net rentable area for properties owned.

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No definition available.

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Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

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-Name Accounting Standards Codification
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Value of preferred stock and warrants for common stock issued.

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- Definition

Detail information of subsequent event by type. User is expected to use existing line items from elsewhere in the taxonomy as the primary line items for this disclosure, which is further associated with dimension and member elements pertaining to a subsequent event.

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No definition available.

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Subsequent Events - Additional Information (Details)			12 Months Ended
Subsequent Events - Additional Information (Details)	Mar. 07, 2017 USD ($) $ / shares	Jan. 07, 2017 USD ($) ft²	Dec. 31, 2016 USD ($)	Nov. 30, 2015 USD ($)	Jul. 31, 2015 USD ($) ft²
Subsequent Event [Line Items]
Lease payments due minimum amount			$ 22,722,000
Hercules \| Loan and Security Agreement
Subsequent Event [Line Items]
Debt Instrument, interest rate terms			The Term Loan will bear interest at a rate equal to the greater of either (i) 7.95% plus the prime rate as reported in the Wall Street Journal minus 3.75%, and (ii) 7.95%.
Debt instrument, payment terms			The Company shall begin to repay the aggregate principal amount that is outstanding in equal monthly installments of principal and interest beginning on July 1, 2018, or if certain clinical development or financing milestones are achieved, beginning on certain dates in 2019, until the Term Loan maturity The Company may voluntarily prepay the term loan, subject to a 2.0% premium for 12 months and a 1.0% premium after 12 months but prior to 24 months.
Subsequent Event \| Hercules \| Loan and Security Agreement
Subsequent Event [Line Items]
Aggregate principal amount of term loan	$ 20,000,000
Term loan drawing date, earliest	Jun. 15, 2017
Term loan drawing date, latest	Sep. 15, 2017
Term loan additional amount drawing date, latest	Dec. 15, 2017
Percentage of interest rate	7.95%
Percentage of interest rate	3.75%
Debt instrument, fee amount	$ 200,000
Percentage of aggregate amount of term loans drawn	5.40%
Debt instrument, maturity date	Dec. 01, 2020
Percentage of aggregate amount of term loan advances funded under loan agreement	3.00%
Warrants issued	$ 150,000,000
Warrant exercise price \| $ / shares	$ 15.13
Subsequent Event \| Hercules \| Loan and Security Agreement \| Maximum
Subsequent Event [Line Items]
Aggregate amount to be drawn under term loan	$ 10,000,000
Additional amount to be drawn under term loan	10,000,000
Subsequent Event \| Hercules \| Loan and Security Agreement \| Minimum
Subsequent Event [Line Items]
Aggregate amount to be drawn under term loan	$ 5,000,000
Manufacturing Space
Subsequent Event [Line Items]
Area of leased space \| ft²					22,000
Lease payments due minimum amount				$ 7,300,000	$ 900,000
Manufacturing Space \| JCN Partners
Subsequent Event [Line Items]
Description of lease term			The long-term lease commences on June 1, 2017, terminates on May 31, 2027 and is extendible for two five year terms at the Company’s election.
Manufacturing Space \| Subsequent Event \| JCN Partners
Subsequent Event [Line Items]
Area of leased space \| ft²		39,599
Lease expiration date		May 31, 2027
Lease payments due minimum amount		$ 7,300,000