Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Schedule of Loss Before Provision for Income Taxes

For financial reporting purposes, “loss before provision for income taxes,” includes the following components:

	For the Year Ended December 31,
	2016			2015			2014
	(in thousands)
Domestic	$	(59,668	)	$	(26,458	)	$	(10,819	)

Schedule of Income Tax Provision (Benefit) Related to Continuing Operations

Income tax provision (benefit) related to continuing operations differ from the amounts computed by applying the statutory income tax rate of 35% to pretax loss as follows:

	For the Year Ended December 31,
	2016			2015			2014
	(in thousands)
At statutory rate	$	(20,884	)	$	(9,260	)	$	(3,788	)
State taxes		1			1			1
Change in valuation allowance		25,483			10,263			3,998
Tax credits		(5,098	)		(1,347	)		(345	)
Stock-based compensation		445			160			60
Other		53			183			74
Total	$	—		$	—		$	—

Schedule of Significant Components of Deferred Tax Assets for Federal and State Income Taxes

Significant components of deferred tax assets for federal and state income taxes are as follows:

	For the Year Ended December 31,
	2016			2015
	(in thousands)
Deferred tax assets:
Federal and state net operating loss carryforward	$	34,921		$	14,286
Research and other credits		11,876			2,858
Intangibles		1,714			1,211
Reserves and accruals		1,802			690
Stock-based compensation		326			22
Start-up costs		160			174
Other		1,091			141
Total gross deferred tax assets		51,890			19,382
Less valuation allowance		(50,678	)		(19,350	)
Total deferred tax assets		1,212			32
Deferred tax liabilities:
Other intangibles		(3,260	)		(3,260	)
Property, plant and equipment		(1,212	)		(32	)
Total gross deferred tax liability		(4,472	)		(3,292	)
Net deferred tax liability	$	(3,260	)	$	(3,260	)

Schedule of Unrecognized Tax Benefits

Unrecognized tax benefits were as follows:

	For the Year Ended December 31,
	2016		2015		2014
	(in thousands)
Beginning balance	$	714	$	121	$	15
Tax positions related to current year:
Federal and state		2,256		593		106
Ending balance	$	2,970	$	714	$	121