144 0001800668 XXXXXXXX LIVE 0001628171 REVOLUTION MEDICINES, INC. 001-39219 700 Saginaw Drive Redwood City CA 94063 6504816801 JACK LEE ANDERS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

10000 627300.00 193319805 11/11/2025 NASDAQ Common 11/11/2025 Exercise of Stock Options Issuer N 10000 11/11/2025 Cash N JACK LEE ANDERS

700 Saginaw Drive Redwood City CA 94063

Common 09/16/2025 2320 106313.77 10b5-1 Sales for JACK LEE ANDERS

700 Saginaw Drive Redwood City CA 94063

Common 09/03/2025 5238 210432.46 10b5-1 Sales for JACK LEE ANDERS

700 Saginaw Drive Redwood City CA 94063

Common 09/02/2025 4762 190560.00 Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday 11/11/2025 12/16/2024 /s/ Jack Lee Anders