X0508 4 2023-10-16 0001628171 Revolution Medicines, Inc. RVMD 0001294192 Horn Margaret A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true Chief Operating Officer true Common Stock 2023-10-16 4 M 0 25000 4.09 A 121960 D Common Stock 2023-10-16 4 S 0 100 30.15 D 121860 D Common Stock 2023-10-16 4 S 0 500 31.956 D 121360 D Common Stock 2023-10-16 4 S 0 800 33.2288 D 120560 D Common Stock 2023-10-16 4 S 0 23200 34.0186 D 97360 D Common Stock 2023-10-16 4 S 0 400 34.995 D 96960 D Stock Option (Right to Buy) 4.09 2023-10-16 4 M 0 25000 0 D 2023-03-13 2029-03-12 Common Stock 25000 78302 D Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 29, 2023. Includes 64,875 restricted stock units. This transaction was executed in multiple trades in prices ranging from $31.41 to $32.40, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. This transaction was executed in multiple trades in prices ranging from $32.72 to $33.61, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. This transaction was executed in multiple trades in prices ranging from $33.73 to $34.66, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. This transaction was executed in multiple trades in prices ranging from $34.76 to $35.18, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. /s/ Jack Anders, as Attorney-in-fact for Margaret Horn 2023-10-18