X0306 4 2022-09-19 0 0001628171 Revolution Medicines, Inc. RVMD 0001294192 Horn Margaret A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 0 1 0 0 See Remarks Common Stock 2022-09-19 4 S 0 1267 19.0426 D 62512 D Common Stock 53302 I Trust Pursuant to an automatic sell-to-cover imposed by the terms of the restricted stock units ("RSUs") award, the shares were sold following the vesting of the RSUs solely to cover applicable withholding taxes. This transaction was executed in multiple trades in prices ranging from $18.9737 to $19.0337, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Includes 43,325 RSUs. Held by Margaret A. Horn Revocable Living Trust. Chief Operating Officer /s/ Jack Anders, as Attorney-in-fact for Margaret Horn 2022-09-21